|
KMID : 0861020150300010001
|
|
Korea Journal of Herbology
2015 Volume.30 No. 1 p.1 ~ p.9
|
|
|
Anti-Diabetic Effects of Mori Folium Extract on High-Fat Diet and Streptozotocin-Induced Type II Diabetes Mellitus in Mice
|
|
Gwon Tae-Oh
Choi Ji-Won
Lee Hyun-Seo
Cho Byoung-Ok
Yin Hong-Hua
Jang Seon-Il
|
|
|
Abstract
|
|
|
Objectives : The present study was designed to investigate the anti-diabetic effects of Mori Folium ( Morus alba L. of Moraceae) extract (MFE) on high fat diet (HFD) and streptozotocin (STZ)-induced type II diabetes mellitus in mice.
Methods : The mice (C57BL/6J) were fed HFD for 8 weeks and then was induced with a single injection of STZ (75 mg/kg). The diabetic mice were divided into four groups [(STD, HFD, HFD + MFE and HFD + quercetin (QUR)] and administered with MFE or OUR for 4 weeks. Fasting blood glucose, lipid profile (triglycerides and cholesterol etc.), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), insulin and leptin were measured every 2 weeks.
Results : Body weight gain was lower in the MFE and QUR groups than HFD group. The fasting blood glucose was lower in the MFE and QUR groups. Oral glucose and insulin tolerance were decreased in the MFE and QUR groups. The levels of serum total cholesterol, triglycerides, and LDL cholesterol were reduced in the MFE and QUR groups. The HDL cholesterol was much higher in the MFE and QUR groups than HFD group. The levels of GOT, GPT and atherogenic index were decreased in the MFE and QUR groups. The serum insulin and leptin concentrations were reduced in the MFE and QUR groups.
Conclusions : These results showed that MFE could decrease blood glucose level and lead to an amelioration in dyslipidemia states on HFD/STZ-induced type II diabetes mellitus in mice.
|
|
|
KEYWORD
|
|
|
Mori Folium extract, Quercetin, Anti-diabetic effects, Blood glucose level, Type II diabetes mellitus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|